Police[]
Barksdale Detail[]
- Lieutentant Cedric Daniels - narcotics shift lieutenant and detail commander
- Detective Jimmy McNulty - case driven but insubordinate homicide investigator who prompted the detail's formation
- Detective Kima Greggs - assigned from narcotics, and Daniels' protege
- Detective Thomas "Herc" Hauk - assigned from narcotics, penchant for physical policing
- Detective Ellis Carver - assigned from narcotics, ambitious
- Detective Roland "Prez" Pryzbylewski - notoriously unreliable South Eastern district detective, reallocated from casualty
- Detective Leander Sydnor - young investigator from South Eastern auto crime unit
- Detective Lester Freamon - older investigator from the pawn shop unit
- Detective Michael Santangelo - white haired investigator assigned from homicide
- Detective Augustus Polk - Alcoholic detective from property crimes unit
- Detective Patrick Mahone - Older detective from property crimes unit
Command[]
- Commissioner Warren Frazier
- Deputy Commissioner of Operations Ervin Burrell
- Major William Rawls - Homicide Unit Commander
- Major Raymond Foerster - Narcotics Unit Commander
- Major Stanislaus Valchek - South Eastern District Commander
- Major Bobby Reed - Internal Investigations Division Commander
Homicide[]
- Sergeant Jay Landsman
- Detective Bunk Moreland
- Detective Ray Cole
- Detective Ed Norris
- Detective Vernon Holley
- Detective Frank Barlow - primary detective in the Pooh Blanchard case
Others[]
- Detective Troy Wiggins - state police narcotics
- Officer Bobby Brown - Western district uniform whose beat includes the Barksdale organization's territory
- Randall Frazier - Baltimore city medical examiner
- Lieutenant Walter Cantrell - commander of Prez and Sydnor's unit
- Lieutenant Torret - leader of the department's Quick Response Team
- Special Agent Terrance "Fitz" Fitzhugh - a friend of McNulty's and an FBI Agent
- Special Agent in Charge Amanda Reese - FBI Supervisor
- Special Agent Arnold D. Paulette - a senior FBI Agent
Relatives[]
- Cheryl - Greggs' domestic partner
- Marla Daniels - Cedric Daniels' wife
- Elena McNulty - Jimmy McNulty's estranged wife
- Sean McNulty - Jimmy McNulty's oldest son
- Michael McNulty - Jimmy McNulty's youngest son
Courthouse[]
- Judge Daniel Phelan - Baltimore circuit court judge
- ASA Rhonda Pearlman - head of narcotics prosecution
- ASA Ilene Nathan - head of violent crimes prosecution
- ASA Taryn Hansen - prosecutor in the D'Angelo Barksdale trial
- ASA Dawkins - prosecutor in the Marvin Browning trial
- AUSA Nadiva Bryant - federal prosecutor with the FBI
- Defense Attorney Maurice Levy - the Barksdale's lawyer
Barksdale organization[]
- Avon Barksdale - drug kingpin
- Russell Bell aka Stringer - Avon's second
- D'Angelo Barksdale aka D - crew chief
- Roland Brice aka Wee-Bey - chief enforcer
- Anton Artis aka Stinkum - an enforcer and lieutenant
- Marquis Hilton aka Bird - a foul mouthed enforcer
- Savino Bratton - a young enforcer
- Wintell Royce aka Little Man - an enforcer at the Franklin Terrace high rises
- Wendell Blocker aka Orlando - front owner of the Barksdale's strip club
- Wallace - a young dealer at the Franklin Terrace low rises
- Preston Broadus aka Bodie - a young drug dealer at the Franklin Terrace low rises
- Malik Carr aka Poot - a young drug dealer at the Franklin Terrace low rises
- Sterling - a young drug dealer at the Franklin Terrace low rises
- Cass - a young drug dealer at the Franklin Terrace low rises
- Herbert De'Rodd Johnson aka Puddin - a young drug dealer at the Franklin Terrace high rises
- Kevin Johnston - a young drug dealer at the Franklin Terrace high rises
- Ronnie Mo - a crew chief
- Marvin Browning - a mid-level drug dealer
- Roc Roc - a a mid-level drug dealer
- CCO - a a mid-level drug dealer
- Perry - a bodyguard
- Donette - D'Angelo's girlfriend
- Chantal - Avon's girlfriend
- Brianna Barksdale - Avon's sister and D'Angelo's mother
Omar's crew[]
- Omar Little - a homosexual stick-up man, who robs the dealers
- Brandon Wright - Omar's romantic and criminal partner
- John Bailey - the third member of Omar's crew
Others[]
- Clay Davis - a corrupt State Senator
- Damien Lavelle Price - an aide to Senator Davis
- William Gant - a maintenance man and witness in D'Angelo's trial
- Nakeesha Lyles - a security guard and witness in D'Angelo's trial
- Scar - Stinkum was killed by Omar trying to take away Scar's corner
- Keisha - a stripper at Orlando's
- Shardene Innes - a stripper at Orlando's that dates D'Angelo
- Bubbles - drug addict, confidential informant and friend of Kima
- Johnny Weeks - drug addict
- Hucklebuck - drug addict
- Rae - Bubbles' sister
- Walon - recovering drug addict
- Mrs. Broadus - Bodie's Grandmother
- Mrs. Bratton - Savino' mother
- Darcia Wallace - Wallace's mother
- Deirdre Kresson - a murder victim found in her apartment
- Tywanda - a friend of Deirdre Kresson
- Pooh Blanchard - murdered by D'Angelo Barksdale
- Taureen Boyd - a murder victim
- Roland Leggett - a murder victim
- Bill Zorzi - a journalist with The Baltimore Sun
- Madame LaRue - a psychic with experience in death investigations
- Roy Brown - an ex-partner of Freamon's