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Initially, she was the head of the violent crimes unit, tasked with prosecuting homicides in the city. As such, she convinced Wee-Bey Brice to plead guilty to multiple murders to avoid the death penalty, and is also present when Savino Bratten confessed to a police-involved shooting.
In Season two, Nathan conducted the prosecution against "Bird" Hilton, reluctantly using Omar Little as a witness. Once Bird was found guilty, she promises Omar a free pass on any single minor charge in the future for his assistance. When Omar is framed for a murder and arrested in Season four, he convinces Detective Bunk Moreland that he is innocent and Bunk convinces Nathan to have him transferred to a safer prison. Nathan tells Bunk that she now considers her debt to Omar repayed.
Later in season four, Nathan helped Detectives Greggs and Norris investigate the Braddock murder case. She also attends the wake of CID and homicide unit commander Raymond Foerster. When Rupert Bond is elected State's attorney he promotes Nathan to second deputy State's Attorney and Pearlman takes over her role in the violent crimes unit.