ER is an Emmy-winning American serial medical drama created by novelist Michael Crichton and set primarily in the emergency room of fictional County General Hospital in Cook County, Chicago, Illinois. It shares several cast and crew members with The Wire.
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- Callie Thorne has a recurring role as Darfur aide worker Jodie Kenyon in season 12 of ER and Elena McNulty in The Wire.
- Maestro Harrell plays musician Todd in the ER season 13 episode "Lights Out" and Randy Wagstaff in The Wire.
- Corey Parker Robinson plays Antoine Bell in season 5 of ER and Detective Leander Sydnor in The Wire.
- Hassan Johnson has a recurring role as Darnell Thibeaux in seasons 11 to 13 of ER and plays criminal enforcer Wee-Bey Brice in The Wire.
- John Doman has a recurring role as Dr. Carl DeRaad in seasons 5 to 9 of ER and plays caustic police commander William Rawls in The Wire.
- Michael Hyatt plays Yvonne Devilliere in the season 13 ER episode "Breach of Trust" and plays Brianna Barksdale in The Wire.
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- David Mills joined the writing staff of ER on the show's fourth season and served as a writer and co-producer on the fifth season. Mills also wrote for the fourth and fifth season of The Wire.
- Ernest R. Dickerson has directed for both series.
- Gloria Muzio has directed for both series.
- Steve Shill has directed for both series.